Lithium Hydroxide → HCID 66918645、化合物

反応式

C([O:3][C:4]([C@@H:6]1[CH2:10][C@@H:9]([S:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)(=[O:13])=[O:12])[CH2:8][C@H:7]1[C:20]([N:22]1[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1)=[O:21])=[O:5])C.[Li+].[OH-]>C1COCC1.O.CO>[C:14]1([S:11]([C@@H:9]2[CH2:10][C@@H:6]([C:4]([OH:5])=[O:3])[C@H:7]([C:20]([N:22]3[CH2:27][CH2:26][O:25][CH2:24][CH2:23]3)=[O:21])[CH2:8]2)(=[O:13])=[O:12])[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

参加物

実験手順

To a solution of (1R,2R,4S)-4-benzenesulfonyl-2-(morpholine-4-carbonyl)-cyclopentanecarboxylic acid ethyl ester (1.35 mmol) in THF (10 ml) was added a solution of LiOH (3.0 mmol) in water (3 ml) and methanol (3 ml) and stirring was continued at 22° C. until completion of the reaction. The mixture was evaporated and the residue partitioned between ethyl acetate and hydrochloric acid (0.1 N). The organic layer was dried and evaporated to give the title compound as a colorless foam. MS: 368.1 (M+H)+.