Isonicotinic Acid → 2,5-Pyrrolidinedione, 1-[(4-pyridinylcarbonyl)oxy]-
反応式
[C:1]([OH:9])(=[O:8])[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.O[N:11]1[C:15](=[O:16])[CH2:14][CH2:13][C:12]1=[O:17]>C1COCC1>[C:1]([O:9][N:11]1[C:15](=[O:16])[CH2:14][CH2:13][C:12]1=[O:17])(=[O:8])[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1参加物
4
実験手順
A mixture of isonicotinic acid (3 g), N-hydroxysuccinimide (2.79 g) and N,N-dicyclohexylcarbodiimide (5.52 g) was stirred in THF (200 mL) for 16 hours. The solid was filtered off and the solvent evaporated under reduced pressure. The residue was triturated with ethyl acetate and more solid filtered off. The filtrates were concentrated under reduced pressure gave 2,5-dioxopyrrolidin-1-yl isonicotinate (5.27 g). MS: 221 [MH]+.
後処理
- filtrationThe solid was filtered off
- customthe solvent evaporated under reduced pressure
- customThe residue was triturated with ethyl acetate and more solid
- filtrationfiltered off
- concentrationThe filtrates were concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-484efae79cfc4124ad2aa9afdd3a06d9
- 出典データセット
- uspto-grants-2003_06
- 特許番号
- US06576630B1
反応ノート
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