Chlorotrimethylsilane → [(1-Ethyl-1-propen-1-yl)oxy]trimethylsilane
反応式
[CH3:1][Si:2]([CH3:5])([CH3:4])Cl.[CH2:6]([C:8]([CH2:10][CH3:11])=[O:9])[CH3:7]>>[CH3:1][Si:2]([CH3:5])([CH3:4])[O:9][C:8]([CH2:10][CH3:11])=[CH:6][CH3:7]参加物
3
実験手順
From reaction between diethylketone and trimethylchlorosilane to form 3-trimethylsilyloxy-2-pentene(1.2.4.17). This product was reacted with 1-fluoropyridinium triflate(1.2.4.5) to obtain 2-fluoro-3-pentanone(1.2.4.9). After bromination with pyridinium bromide followed by reduction using diborane 2-fluoro-4-bromopentane-3-ol(1.2.4.18) was obtained. Reaction of this product with sodium methylate yielded the title compound (1.2.4.16). This compound was made also by reacting 2-(1-bromoethyl)-3-methyl oxirane(1.2.4.13) with HF/Py (70%) followed by treatment of the resulting 2-bromo-4-fluoropentan-3-ol(1.2.4.18) with K2CO3/MeOH.
出典と根拠
- ORDレコード
- ord-3ff2deed151246f1b54dbd26f95b6898
- 出典データセット
- uspto-grants-2003_06
- 特許番号
- US06583182B1
反応ノート
読み込み中…