Sodium Hydroxide → 3-chloro-4-(N-(3-indolylcarbonyl)amino)phenylacetic acid

反応式

[Cl:1][C:2]1[CH:3]=[C:4]([CH2:20][C:21]([O:23]CC)=[O:22])[CH:5]=[CH:6][C:7]=1[NH:8][C:9]([C:11]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[NH:13][CH:12]=1)=[O:10].[OH-].[Na+]>C1COCC1.Cl>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:20][C:21]([OH:23])=[O:22])[CH:5]=[CH:6][C:7]=1[NH:8][C:9]([C:11]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[NH:13][CH:12]=1)=[O:10]

参加物

実験手順

To a solution of ethyl 3-chloro-4-(3-indolylcarbonylamino)phenylacetate (1.25 g, 3.50 mmol) in THF (35 mL) was added 0.25N NaOH (21 mL, 5.23 mmol) under stirring. The reaction mixture was then stirred at room temperature for 24 hours. The reaction mixture was poured in 1N HCl (30 ml) under stirring at 0° C. The crystals thus precipitated were collected by filtration, whereby 3-chloro-4-(N-(3-indolylcarbonyl)amino)phenylacetic acid (1.05 g, 91%) was obtained as a colorless solid.