Tetrahydrofuran → 3-Chloro-4-(1-indolinylcarbonylamino)phenylacetic acid

反応式

[Cl:1][C:2]1[CH:3]=[C:4]([CH2:20][C:21]([O:23]CC)=[O:22])[CH:5]=[CH:6][C:7]=1[NH:8][C:9]([N:11]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:13][CH2:12]1)=[O:10].[OH-].[Na+].C1COCC1>Cl>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:20][C:21]([OH:23])=[O:22])[CH:5]=[CH:6][C:7]=1[NH:8][C:9]([N:11]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:13][CH2:12]1)=[O:10]

参加物

実験手順

To ethyl 3-chloro-4-(1-indolinylcarbonylamino)phenylacetate (3.07 g, 8.56 mmol) were added 0.25N NaOH (68.4 ml, 17.1 mmol) and THF (70 ml). The mixture was heated and refluxed for 4 hours. After cooling, the reaction mixture was poured in 1N hydrochloric acid (50 ml). The crystals thus precipitated were collected by filtration, and dried under reduced pressure for 12 hours, whereby 3-chloro-4-(1-indolinylcarbonylamino)phenylacetic acid (1.71 g, 60%) was obtained as a colorless crystalline powder.