Sodium Hydroxide → (3-Chloro-4-(6-fluoro-2-benzothiazolyl)aminophenyl)acetic acid

HRID 1372673ノート

反応式

HRID 1372673 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:19][C:20]([O:22]C)=[O:21])[CH:5]=[CH:6][C:7]=1[NH:8][C:9]1[S:10][C:11]2[CH:17]=[C:16]([F:18])[CH:15]=[CH:14][C:12]=2[N:13]=1.[OH-].[Na+]>C1COCC1>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:19][C:20]([OH:22])=[O:21])[CH:5]=[CH:6][C:7]=1[NH:8][C:9]1[S:10][C:11]2[CH:17]=[C:16]([F:18])[CH:15]=[CH:14][C:12]=2[N:13]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 58778884Methyl (3-chloro-4-(6-fluoro-2-benzothiazolyl)aminophenyl)acetate

生成物 1

HCID 17859168(3-Chloro-4-(6-fluoro-2-benzothiazolyl)aminophenyl)acetic acid収率 84%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Methyl (3-chloro-4-(6-fluoro-2-benzothiazolyl)aminophenyl)acetate (158 mg, 0.45 mmol) was dissolved in THF (3 ml). To the resulting solution was added 0.5N NaOH (3.0 ml, 1.50 mmol), and the resulting mixture was stirred at room temperature for 18 hours. The mixture was poured in ice-1N HCl. The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure to give (3-chloro-4-(6-fluoro-2-benzothiazolyl)aminophenyl)acetic acid (127 mg, 84%) as a pale yellow solid.

後処理

  1. customThe crystals thus precipitated
  2. filtrationwere collected by filtration under reduced pressure
  3. washwashed with water
  4. customdried under reduced pressure

出典と根拠

ORDレコード
ord-60662585a9744974962dc060f19ae21a
出典データセット
uspto-grants-2007_01
特許番号
US07157487B2

反応ノート

読み込み中…