Sodium Hydroxide → (3-Chloro-4-(6-methyl-2-benzothiazolyl)aminophenyl)acetic acid

HRID 1372675

反応式

HRID 1372675 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:19][C:20]([O:22]C)=[O:21])[CH:5]=[CH:6][C:7]=1[NH:8][C:9]1[S:10][C:11]2[CH:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:12]=2[N:13]=1.[OH-].[Na+]>C1COCC1>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:19][C:20]([OH:22])=[O:21])[CH:5]=[CH:6][C:7]=1[NH:8][C:9]1[S:10][C:11]2[CH:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:12]=2[N:13]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 58778443Methyl (3-chloro-4-(6-methyl-2-benzothiazolyl)aminophenyl)acetate

生成物 1

HCID 17858843(3-Chloro-4-(6-methyl-2-benzothiazolyl)aminophenyl)acetic acid収率 77%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Methyl (3-chloro-4-(6-methyl-2-benzothiazolyl)aminophenyl)acetate (274 mg, 0.79 mmol) was dissolved in THF (5 ml). To the resulting solution was added 0.5N NaOH (5.0 ml, 2.50 mmol), followed by stirring at room temperature for 15 hours. The reaction mixture was poured in ice-1N HCR. The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure to give (3-chloro-4-(6-methyl-2-benzothiazolyl)aminophenyl)acetic acid (202 mg, 77%) as a pale yellow solid.

後処理

  1. customThe crystals thus precipitated
  2. filtrationwere collected by filtration under reduced pressure
  3. washwashed with water
  4. customdried under reduced pressure

出典と根拠

ORDレコード
ord-53a24afdd19748c783a8fbeaf88056cd
出典データセット
uspto-grants-2007_01
特許番号
US07157487B2

関連ノート

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