Sodium Hydroxide → (4-(6-Chloro-2-benzothiazolyl)amino-3-chlorophenyl)acetic acid

HRID 1372677

反応式

HRID 1372677 の反応式
[Cl:1][C:2]1[CH:23]=[CH:22][C:5]2[N:6]=[C:7]([NH:9][C:10]3[CH:15]=[CH:14][C:13]([CH2:16][C:17]([O:19]C)=[O:18])=[CH:12][C:11]=3[Cl:21])[S:8][C:4]=2[CH:3]=1.[OH-].[Na+]>C1COCC1>[Cl:1][C:2]1[CH:23]=[CH:22][C:5]2[N:6]=[C:7]([NH:9][C:10]3[CH:15]=[CH:14][C:13]([CH2:16][C:17]([OH:19])=[O:18])=[CH:12][C:11]=3[Cl:21])[S:8][C:4]=2[CH:3]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 58778710Methyl (4-(6-chloro-2-benzothiazolyl)amino-3-chlorophenyl)acetate

生成物 1

HCID 17859264(4-(6-Chloro-2-benzothiazolyl)amino-3-chlorophenyl)acetic acid収率 95%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Methyl (4-(6-chloro-2-benzothiazolyl)amino-3-chlorophenyl)acetate (271 mg, 0.74 mmol) was dissolved in THF (4.5 ml). To the resulting solution was added 0.5N NaOH (4.5 ml, 2.25 mmol), followed by stirring at room temperature for 15 hours. The reaction mixture was poured in ice-1N HCl. The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure to give (4-(6-chloro-2-benzothiazolyl)amino-3-chlorophenyl)acetic acid (248 mg, 95%) as a pale yellow solid.

後処理

  1. customThe crystals thus precipitated
  2. filtrationwere collected by filtration under reduced pressure
  3. washwashed with water
  4. customdried under reduced pressure

出典と根拠

ORDレコード
ord-58fdca4463604b758be4983dfb04ed57
出典データセット
uspto-grants-2007_01
特許番号
US07157487B2

関連ノート

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