Sodium Hydroxide → (3-Chloro-4-(5-fluoro-2-benzothiazolyl)aminophenyl)acetic acid

HRID 1372682

反応式

HRID 1372682 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:19][C:20]([O:22]C)=[O:21])[CH:5]=[CH:6][C:7]=1[NH:8][C:9]1[S:10][C:11]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][C:12]=2[N:13]=1.[OH-].[Na+]>C1COCC1>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:19][C:20]([OH:22])=[O:21])[CH:5]=[CH:6][C:7]=1[NH:8][C:9]1[S:10][C:11]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][C:12]=2[N:13]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 58778358Methyl (3-chloro-4-(5-fluoro-2-benzothiazolyl)aminophenyl)acetate

生成物 1

HCID 17858868(3-Chloro-4-(5-fluoro-2-benzothiazolyl)aminophenyl)acetic acid収率 81%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

In THF (5 ml) was dissolved methyl (3-chloro-4-(5-fluoro-2-benzothiazolyl)aminophenyl)acetate (292 mg, 0.83 mmol). To the resulting solution was added 0.5N NaOH (5.0 ml, 2.50 mmol). The resulting mixture was stirred at room temperature for 2 hours. The reaction mixture was poured in ice-1N HCl. The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure to give (3-chloro-4-(5-fluoro-2-benzothiazolyl)aminophenyl)acetic acid (226 mg, 81%) as a pale solid.

後処理

  1. customThe crystals thus precipitated
  2. filtrationwere collected by filtration under reduced pressure
  3. washwashed with water
  4. customdried under reduced pressure

出典と根拠

ORDレコード
ord-3129941e178349838dabe2924d3e82e0
出典データセット
uspto-grants-2007_01
特許番号
US07157487B2

関連ノート

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