Sodium Hydroxide → (5-Chloro-4-(5-fluoro-2-benzothiazolyl)amino-2-fluorophenyl)acetic acid

HRID 1372684

反応式

HRID 1372684 の反応式
[Cl:1][C:2]1[C:3]([NH:15][C:16]2[S:17][C:18]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:19]=3[N:20]=2)=[CH:4][C:5]([F:14])=[C:6]([CH2:8][C:9]([O:11]CC)=[O:10])[CH:7]=1.[OH-].[Na+]>C1COCC1>[Cl:1][C:2]1[C:3]([NH:15][C:16]2[S:17][C:18]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:19]=3[N:20]=2)=[CH:4][C:5]([F:14])=[C:6]([CH2:8][C:9]([OH:11])=[O:10])[CH:7]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 58778765Ethyl (5-chloro-4-(5-fluoro-2-benzothiazolyl)amino-2-fluorophenyl)acetate

生成物 1

HCID 17859016(5-Chloro-4-(5-fluoro-2-benzothiazolyl)amino-2-fluorophenyl)acetic acid収率 86%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Ethyl (5-chloro-4-(5-fluoro-2-benzothiazolyl)amino-2-fluorophenyl)acetate (298 mg, 0.78 mmol) was dissolved in THF (5 ml). To the resulting solution was added 0.5N NaOH (5.0 ml, 2.50 mmol). The resulting mixture was stirred at room temperature for 3 hours. The reaction mixture was poured in ice-1N HCl. The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure to give (5-chloro-4-(5-fluoro-2-benzothiazolyl)amino-2-fluorophenyl)acetic acid (237 mg, 86%) as a pale yellow solid.

後処理

  1. customThe crystals thus precipitated
  2. filtrationwere collected by filtration under reduced pressure
  3. washwashed with water
  4. customdried under reduced pressure

出典と根拠

ORDレコード
ord-6eed12fa04614de5ba0408d49f072efe
出典データセット
uspto-grants-2007_01
特許番号
US07157487B2

関連ノート

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