Hydrochloric Acid → 1-(1-Methylethyl)-1H-indole-3-carboxylic acid

HRID 1372692ノート

反応式

HRID 1372692 の反応式
[CH:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([C:13]([O:15]C)=[O:14])=[CH:5]1)([CH3:3])[CH3:2].[OH-].[Na+].Cl>C1COCC1>[CH:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([C:13]([OH:15])=[O:14])=[CH:5]1)([CH3:3])[CH3:2]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 10443342Methyl 1-(1-methylethyl)-1H-indole-3-carboxylate

生成物 1

HCID 103979731-(1-Methylethyl)-1H-indole-3-carboxylic acid収率 90.4%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
50 °C

実験手順

In THF (8.0 ml) was dissolved methyl 1-isopropylindole-3-carboxylate (387.6 mg, 1.784 mmol). To the resulting solution was added 0.25N NaOH (8.0 ml). The resulting mixture was stirred at 50° C. for 18 hours. After cooling to room temperature, the reaction mixture was acidified with 1N HCl (4.5 ml). The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure to give 1-isopropylindole-3-carboxylic acid (327.8 mg, 90%) as a pale pink amorphous substance.

後処理

  1. temperatureAfter cooling to room temperature
  2. customThe crystals thus precipitated
  3. filtrationwere collected by filtration under reduced pressure
  4. washwashed with water
  5. customdried under reduced pressure

出典と根拠

ORDレコード
ord-65d9c0157ad14ecfb548ad0e660868ee
出典データセット
uspto-grants-2007_01
特許番号
US07157487B2

反応ノート

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