Sodium Hydroxide → HCID 17859077、化合物

HRID 1372694ノート

反応式

HRID 1372694 の反応式
[OH-].[Na+].[Cl:3][C:4]1[CH:5]=[C:6]([CH2:25][C:26]([O:28]C)=[O:27])[CH:7]=[CH:8][C:9]=1[NH:10][C:11]([C:13]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[N:15]([CH:22]([CH3:24])[CH3:23])[CH:14]=1)=[O:12]>C1COCC1>[Cl:3][C:4]1[CH:5]=[C:6]([CH2:25][C:26]([OH:28])=[O:27])[CH:7]=[CH:8][C:9]=1[NH:10][C:11]([C:13]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[N:15]([CH:22]([CH3:23])[CH3:24])[CH:14]=1)=[O:12]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 17859043HCID 17859043、化合物

生成物 1

HCID 17859077HCID 17859077、化合物収率 93%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
50 °C

実験手順

In THF (6.0 ml) was dissolved the methyl 3-chloro-4-((1-isopropyl-3-indolylcarbonyl)amino)phenylacetate obtained in the above-described (Step 3). To the resulting solution was added 0.25N NaOH (6.0 ml), followed by stirring at 50° C. for 18 hours. After cooling, the reaction mixture was distilled under reduced pressure to remove the solvent. The resulting residue was acidified with 1N HCl (2.0 ml). The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure to give 3-chloro-4-((1-isopropyl-3-indolylcarbonyl)amino)phenylacetic acid (246.2 mg, 93%) as a brown amorphous substance.

後処理

  1. customobtained in the above-described (Step 3)
  2. temperatureAfter cooling
  3. distillationthe reaction mixture was distilled under reduced pressure
  4. customto remove the solvent
  5. customThe crystals thus precipitated
  6. filtrationwere collected by filtration under reduced pressure
  7. washwashed with water
  8. customdried under reduced pressure

出典と根拠

ORDレコード
ord-ad7c951aa88d4cba8570d2040ffc3a33
出典データセット
uspto-grants-2007_01
特許番号
US07157487B2

反応ノート

読み込み中…