Sodium Hydroxide → HCID 17858998、化合物

HRID 1372704

反応式

HRID 1372704 の反応式
[Cl:1][C:2]1[C:3]([NH:15][C:16]([C:18]2[C:26]3[C:21](=[CH:22][C:23]([F:27])=[CH:24][CH:25]=3)[N:20]([CH3:28])[CH:19]=2)=[O:17])=[CH:4][C:5]([F:14])=[C:6]([CH2:8][C:9]([O:11]CC)=[O:10])[CH:7]=1.[OH-].[Na+]>C1COCC1.Cl>[Cl:1][C:2]1[C:3]([NH:15][C:16]([C:18]2[C:26]3[C:21](=[CH:22][C:23]([F:27])=[CH:24][CH:25]=3)[N:20]([CH3:28])[CH:19]=2)=[O:17])=[CH:4][C:5]([F:14])=[C:6]([CH2:8][C:9]([OH:11])=[O:10])[CH:7]=1

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 58778583Ethyl (5-chloro-2-fluoro-4-((6-fluoro-1-methyl-3-indolylcarbonyl)amino)phenyl)acetate

生成物 1

HCID 17858998HCID 17858998、化合物収率 97.2%

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

In THF (17 ml) was dissolved ethyl (5-chloro-2-fluoro-4-((6-fluoro-1-methyl-3-indolylcarbonyl)amino)phenyl)acetate (665 mg, 1.63 mmol). To the resulting solution was added 0.25N NaOH (9.81 ml, 2.45 mmol) and the mixture was stirred at room temperature for 14 hours. The reaction mixture was poured in 1N HCl (3.0 ml). The crystals thus precipitated were collected by filtration under reduced pressure, washed with water, and dried under reduced pressure to give (5-chloro-2-fluoro-4-((6-fluoro-1-methyl-3-indolylcarbonyl)amino)phenyl)acetic acid (600 mg, 97%) as a brown solid.

後処理

  1. customThe crystals thus precipitated
  2. filtrationwere collected by filtration under reduced pressure
  3. washwashed with water
  4. customdried under reduced pressure

出典と根拠

ORDレコード
ord-06cb9ecb215940f389b5ff3fa3acb3ec
出典データセット
uspto-grants-2007_01
特許番号
US07157487B2

関連ノート

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