Hydrochloric Acid → (3-Bromo-4-((1-isoquinolinylcarbonyl)amino)phenyl)acetic acid

HRID 1372720

反応式

HRID 1372720 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH2:21][C:22]([O:24]CC)=[O:23])[CH:5]=[CH:6][C:7]=1[NH:8][C:9]([C:11]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:14]=[CH:13][N:12]=1)=[O:10].[OH-].[Na+].Cl>C1COCC1>[Br:1][C:2]1[CH:3]=[C:4]([CH2:21][C:22]([OH:24])=[O:23])[CH:5]=[CH:6][C:7]=1[NH:8][C:9]([C:11]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:14]=[CH:13][N:12]=1)=[O:10]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 58778618Ethyl (3-bromo-4-((1-isoquinolinylcarbonyl)amino)phenyl)acetate

生成物 1

HCID 17859108(3-Bromo-4-((1-isoquinolinylcarbonyl)amino)phenyl)acetic acid収率 98.1%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Ethyl (3-bromo-4-((1-isoquinolinylcarbonyl)amino)phenyl)acetate (1.64 g, 3.97 mmol) was dissolved in THF (40 ml). To the resulting solution was added 0.25N NaOH (24.0 ml, 5.95 mmol), and the mixture was stirred at room temperature for 8 hours. The reaction mixture was poured into 1N HCl (50 ml) to acidify the mixture. The crystals thus precipitated were collected by filtration under reduced pressure, washed with water, and dried under reduced pressure to give (3-bromo-4-((1-isoquinolinylcarbonyl)amino)phenyl)acetic acid (1.50 g, 98%) as a pale yellow solid.

後処理

  1. customThe crystals thus precipitated
  2. filtrationwere collected by filtration under reduced pressure
  3. washwashed with water
  4. customdried under reduced pressure

出典と根拠

ORDレコード
ord-32f773e534ce42acac00bdeb04ff47cd
出典データセット
uspto-grants-2007_01
特許番号
US07157487B2

関連ノート

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