Hydrochloric Acid → HCID 17858761、化合物

反応式

[Cl:1][C:2]1[CH:3]=[C:4]([CH2:21][C:22]([O:24]C)=[O:23])[CH:5]=[CH:6][C:7]=1[NH:8][C:9]([C:11]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:14]=[CH:13][N:12]=1)=[O:10].[OH-].[Na+].Cl>C1COCC1>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:21][C:22]([OH:24])=[O:23])[CH:5]=[CH:6][C:7]=1[NH:8][C:9]([C:11]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:14]=[CH:13][N:12]=1)=[O:10]

参加物

実験手順

Methyl (3-chloro-4-((1-isoquinolinylcarbonyl)amino)phenyl)acetate (1.14 g, 3.21 mmol) was dissolved in THF (33 ml). To the resulting solution was added 0.25N NaOH (19.3 ml, 4.82 mmol), and the mixture was stirred at room temperature for 14 hours. The reaction mixture was poured into 1N HCl (5.0 ml). The crystals thus precipitated were collected by filtration under reduced pressure, washed with water, and dried under reduced pressure to give (3-chloro-4-((1-isoquinolinylcarbonyl)amino)phenyl)acetic acid (1.07 g, 98%) as a brown solid.