Sodium Hydroxide → 2-Methyl-2H-indazole-3-carboxylic acid

HRID 1372741

反応式

HRID 1372741 の反応式
[CH3:1][N:2]1[C:10]([C:11]([O:13]C)=[O:12])=[C:9]2[C:4]([CH:5]=[CH:6][CH:7]=[CH:8]2)=[N:3]1.[OH-].[Na+]>C1COCC1>[CH3:1][N:2]1[C:10]([C:11]([OH:13])=[O:12])=[C:9]2[C:4]([CH:5]=[CH:6][CH:7]=[CH:8]2)=[N:3]1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 11658425Methyl 2-methyl-2H-indazole-3-carboxylate

生成物 1

HCID 70605372-Methyl-2H-indazole-3-carboxylic acid収率 91%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To methyl 2-methylindazole-3-carboxylate (1.59 g, 8.36 mmol) were added THF (85 ml) and 0.25N NaOH (50 ml, 12.5 mmol) and the resulting mixture was stirred at room temperature for 24 hours. The reaction mixture was distilled under reduced pressure to remove the solvent. To the residue was added water, followed by the addition of 1N HCl (50 ml). The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure to give 2-methylindazole-3-carboxylic acid (1.34 g, 91%) as a colorless solid.

後処理

  1. distillationThe reaction mixture was distilled under reduced pressure
  2. customto remove the solvent
  3. additionTo the residue was added water
  4. additionfollowed by the addition of 1N HCl (50 ml)
  5. customThe crystals thus precipitated
  6. filtrationwere collected by filtration under reduced pressure
  7. washwashed with water
  8. customdried under reduced pressure

出典と根拠

ORDレコード
ord-a49fee857c3c4b2b856781d27004a7ab
出典データセット
uspto-grants-2007_01
特許番号
US07157487B2

関連ノート

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