Sodium Hydroxide → 2-Methyl-2H-indazole-3-carboxylic acid
反応式
[CH3:1][N:2]1[C:10]([C:11]([O:13]C)=[O:12])=[C:9]2[C:4]([CH:5]=[CH:6][CH:7]=[CH:8]2)=[N:3]1.[OH-].[Na+]>C1COCC1>[CH3:1][N:2]1[C:10]([C:11]([OH:13])=[O:12])=[C:9]2[C:4]([CH:5]=[CH:6][CH:7]=[CH:8]2)=[N:3]1参加物
4
実験手順
To methyl 2-methylindazole-3-carboxylate (1.59 g, 8.36 mmol) were added THF (85 ml) and 0.25N NaOH (50 ml, 12.5 mmol) and the resulting mixture was stirred at room temperature for 24 hours. The reaction mixture was distilled under reduced pressure to remove the solvent. To the residue was added water, followed by the addition of 1N HCl (50 ml). The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure to give 2-methylindazole-3-carboxylic acid (1.34 g, 91%) as a colorless solid.
後処理
- distillationThe reaction mixture was distilled under reduced pressure
- customto remove the solvent
- additionTo the residue was added water
- additionfollowed by the addition of 1N HCl (50 ml)
- customThe crystals thus precipitated
- filtrationwere collected by filtration under reduced pressure
- washwashed with water
- customdried under reduced pressure
出典と根拠
- ORDレコード
- ord-a49fee857c3c4b2b856781d27004a7ab
- 出典データセット
- uspto-grants-2007_01
- 特許番号
- US07157487B2
反応ノート
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