Tetrahydrofuran → (3-Chloro-4-((1-methyl-3-indazolylcarbonyl)amino)phenyl)acetic acid

HRID 1372745

反応式

HRID 1372745 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:21][C:22]([O:24]C)=[O:23])[CH:5]=[CH:6][C:7]=1[NH:8][C:9]([C:11]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]([CH3:20])[N:12]=1)=[O:10].C1COCC1.[OH-].[Na+]>Cl>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:21][C:22]([OH:24])=[O:23])[CH:5]=[CH:6][C:7]=1[NH:8][C:9]([C:11]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]([CH3:20])[N:12]=1)=[O:10]

参加物

5

反応物 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 58778393Methyl (3-chloro-4-((1-methyl-3-indazolylcarbonyl)amino)phenyl)acetate

生成物 1

HCID 17858964(3-Chloro-4-((1-methyl-3-indazolylcarbonyl)amino)phenyl)acetic acid収率 95.4%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

To methyl (3-chloro-4-((1-methyl-3-indazolylcarbonyl)amino)phenyl)acetate (1.08 g, 3.02 mmol) were added THF (30 ml) and 0.25N NaOH (18.1 ml, 4.53 mmol) and the resulting mixture was stirred at room temperature for 16 hours. The reaction mixture was poured in 1N HCl (5.0 ml). The crystals thus precipitated were collected by filtration under reduced pressure, washed with water, and dried under reduced pressure to give (3-chloro-4-((1-methyl-3-indazolylcarbonyl)amino)phenyl)acetic acid (0.99 g, 95%) as a brown solid.

後処理

  1. customThe crystals thus precipitated
  2. filtrationwere collected by filtration under reduced pressure
  3. washwashed with water
  4. customdried under reduced pressure

出典と根拠

ORDレコード
ord-cfdf65ddbf564163a331a71c8e55848f
出典データセット
uspto-grants-2007_01
特許番号
US07157487B2

関連ノート

読み込み中…