6-Nitro-2,3-dihydro-benzo[1,4]oxathiine-4,4-dioxide → 6-Amino-2,3-dihydro-1,4

HRID 1373719ノート

反応式

HRID 1373719 の反応式
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[O:12][CH2:11][CH2:10][S:9](=[O:14])(=[O:13])[C:8]=2[CH:15]=1)([O-])=O.[H][H]>C1COCC1.CO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]2[O:12][CH2:11][CH2:10][S:9](=[O:14])(=[O:13])[C:8]=2[CH:15]=1

参加物

6

反応物 2

HCID 219881646-Nitro-2,3-dihydro-benzo[1,4]oxathiine-4,4-dioxideHCID 178418361HCID 178418361、化合物

生成物 1

HCID 219881516-Amino-2,3-dihydro-1,4収率 46.4%

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

0.917 g 6-Nitro-2,3-dihydro-benzo[1,4]oxathiine-4,4-dioxide (from g)) were hydrogenated in a mixture of 20 ml THF and 20 ml MeOH with 0.90 g 5% Pd—C at atmospheric hydrogen pressure for 90 min. at room temperature. The catalyst was filtered off, the filtrate evaporated and the residue chromatographed on silica to yield 370 mg of the title compound.

後処理

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate evaporated
  3. customthe residue chromatographed on silica

出典と根拠

ORDレコード
ord-ef96b7afa3474a44a6945b1e95e04c89
出典データセット
uspto-grants-2007_01
特許番号
US07163941B2

反応ノート

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