Succinic anhydride → 4-(4-methylpiperazin-1-yl)-4-oxobutanoic acid

HRID 1374600ノート

反応式

HRID 1374600 の反応式
[C:1]1(=[O:7])[O:6][C:4](=[O:5])[CH2:3][CH2:2]1.[CH3:8][N:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1>O1CCOCC1>[CH3:8][N:9]1[CH2:14][CH2:13][N:12]([C:1](=[O:7])[CH2:2][CH2:3][C:4]([OH:6])=[O:5])[CH2:11][CH2:10]1

参加物

4

反応物 2

HCID 7922Succinic anhydrideHCID 531671-Methylpiperazine

生成物 1

HCID 7393184-(4-methylpiperazin-1-yl)-4-oxobutanoic acid

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

1.17 g of succinic anhydride and then 1.19 cm3 of N-methylpiperazine are added to 20 cm3 of dioxane. After stirring for 18 hours at room temperature, the precipitate obtained is filtered, rinsed with a minimum of dioxane and then, successively, with twice 10 cm3 of acetone and 10 cm3 of diethyl ether. After drying under reduced pressure (2.7 kPa) at 20° C., 1.09 g of 4-(4-methylpiperazin-1-yl)-4-oxobutyric acid are obtained in the form of a white solid melting at 114° C.

後処理

  1. customthe precipitate obtained
  2. filtrationis filtered
  3. washrinsed with a minimum of dioxane
  4. customAfter drying under reduced pressure (2.7 kPa) at 20° C.

出典と根拠

ORDレコード
ord-522f91ae7ec8485b9ec402a472fda927
出典データセット
uspto-grants-2007_01
特許番号
US07166594B2

反応ノート

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