Chloroacetyl chloride → 2-chloro-N,N-diphenyl-Acetamide

HRID 1374837

反応式

HRID 1374837 の反応式
[Cl:1][CH2:2][C:3](Cl)=[O:4].[C:6]1([NH:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>C1(C)C=CC=CC=1.O1CCCC1>[Cl:1][CH2:2][C:3]([N:12]([C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:4]

参加物

5

反応物 2

HCID 6577Chloroacetyl chlorideHCID 11487Diphenylamine

生成物 1

HCID 2244812-chloro-N,N-diphenyl-Acetamide収率 75.5%

試薬・触媒・溶媒 2

HCID 1140Toluene溶媒HCID 8028Tetrahydrofuran溶媒

反応条件

温度
100 °C

実験手順

Chloroacetyl chloride (0.32 ml, 4.02 mmol) was dissolved in a mixed solvent of toluene (6 ml) and tetrahydrofuran (2 ml). The solution was added with diphenylamine (690 mg, 4.08 mmol) at room temperature, and the heated at 100° C. for 80 minutes. The solvent was evaporated under reduced pressure, and the solid precipitated was suspended and washed in ethyl ether. The solid was collected by filtration and dried under reduced pressure to obtain the title compound as colorless solid (746 mg, yield: 75%).

後処理

  1. customThe solvent was evaporated under reduced pressure
  2. customthe solid precipitated
  3. washwashed in ethyl ether
  4. filtrationThe solid was collected by filtration
  5. customdried under reduced pressure

出典と根拠

ORDレコード
ord-f223e951be944d738507469f0bceee6f
出典データセット
uspto-grants-2007_01
特許番号
US07166617B2

関連ノート

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