Sodium Hydroxide → 5-Methyl-3-phenylisoxazole-4-carboxylic acid

HRID 1375633

反応式

HRID 1375633 の反応式
C[O:2][C:3]([C:5]1[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[N:7][O:8][C:9]=1[CH3:10])=[O:4].[OH-].[Na+]>CO.O>[CH3:10][C:9]1[O:8][N:7]=[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:5]=1[C:3]([OH:4])=[O:2]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 727920Methyl 5-methyl-3-phenyl-1,2-oxazole-4-carboxylate

生成物 1

HCID 143435-Methyl-3-phenylisoxazole-4-carboxylic acid収率 72%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

To 5-Methyl-3-phenyl-isoxazole-4-carboxylic acid methyl ester (0.853 g, 3.69 mmol) in methanol (12 mL) was added 2N NaOH (8 mL) the reaction solution was stirred at ambient temperature for 60 hr. The solution was dilute with water and extracted twice with ethyl acetate. The combined extract was washed with brine and dried over MgSO4 and concentrated. Recrystallization (hexanes/ethyl acetate) afforded a white solid (0.540 g, 72% yield).

後処理

  1. extractionextracted twice with ethyl acetate
  2. extractionThe combined extract
  3. washwas washed with brine
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated
  6. customRecrystallization (hexanes/ethyl acetate)

出典と根拠

ORDレコード
ord-b96d7a5e95cf41579c754086b5928b63
出典データセット
uspto-grants-2007_01
特許番号
US07169798B2

関連ノート

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