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Sodium Carbonate → N,O-di-(3,5-di-t-butyl-4-hydroxy-phenylacetyl)-6-amino-2-bromo-4-chloro-phenol

HRID 1377537
ノート
印刷プレビュー

反応式

HRID 1377537 の反応式
[C:1](=[O:4])([O-])[O-:2].[Na+].[Na+].[NH2:7][C:8]1[C:13](O)=[C:12]([Br:15])[CH:11]=[C:10]([Cl:16])[CH:9]=1.[C:17]([C:21]1[CH:22]=[C:23]([CH2:32][C:33](Cl)=[O:34])[CH:24]=[C:25]([C:28]([CH3:31])([CH3:30])[CH3:29])[C:26]=1[OH:27])([CH3:20])([CH3:19])[CH3:18].S(Cl)(Cl)=O>O>[C:17]([C:21]1[CH:22]=[C:23]([CH2:32][C:33]([NH:7][C:8]2[C:13]([O:2][C:1](=[O:4])[CH2:32][C:23]3[CH:22]=[C:21]([C:17]([CH3:18])([CH3:20])[CH3:19])[C:26]([OH:27])=[C:25]([C:28]([CH3:31])([CH3:30])[CH3:29])[CH:24]=3)=[C:12]([Br:15])[CH:11]=[C:10]([Cl:16])[CH:9]=2)=[O:34])[CH:24]=[C:25]([C:28]([CH3:31])([CH3:30])[CH3:29])[C:26]=1[OH:27])([CH3:20])([CH3:19])[CH3:18]
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 10340Sodium CarbonateHCID 24386Thionyl ChlorideHCID 107316503,5-Di-t-butyl-4-hydroxy-phenylacetyl chlorideHCID 155210892-Amino-6-bromo-4-chlorophenol

生成物 1

HCID 15521188N,O-di-(3,5-di-t-butyl-4-hydroxy-phenylacetyl)-6-amino-2-bromo-4-chloro-phenol収率 103.6%

試薬・触媒・溶媒 1

HCID 962
Water
溶媒

実験手順

Water (173 ml) and sodium carbonate (33.24 g, 310 mM) were added to a stirred ethereal solution (123 ml) of 6-amino-2-bromo-4-chloro-phenol (17.45 g, 78.4 mM). After 15 minutes 3,5-di-t-butyl-4-hydroxy-phenylacetyl chloride (47.60 g, 93.1%, 156.8 mM) (prepared with thionyl chloride from the corresponding acid), was added at -5° to 0° C. and stirring continued for a further 1.5 hours without cooling. The aqueous phase was adjusted to pH 8 and the layers separated. The organics were washed with 1N HCl (100 ml) and saturated aqueous sodium bicarbonate solution (100 ml), dried (Na2SO4) and evaporated in-vacuo to give 58.1 g (103.6%) of the title compound which was suitable for the next step.

後処理

  1. additionwas added at -5° to 0° C.
  2. temperaturewithout cooling
  3. customthe layers separated
  4. washThe organics were washed with 1N HCl (100 ml) and saturated aqueous sodium bicarbonate solution (100 ml)
  5. dry with materialdried (Na2SO4)
  6. customevaporated in-vacuo

出典と根拠

ORDレコード
ord-38fede7e3c3e478bb583dbd2b2a59cfe
出典データセット
uspto-grants-1997_09
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US05665737

反応ノート

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