Formaldehyde → 2-(1-Methylpiperidin-4-yl)acetic acid

HRID 1379664ノート

反応式

HRID 1379664 の反応式
[NH:1]1[CH2:6][CH2:5][CH:4]([CH2:7][C:8]([OH:10])=[O:9])[CH2:3][CH2:2]1.[CH2:11]=O>O.[Pd]>[CH3:11][N:1]1[CH2:6][CH2:5][CH:4]([CH2:7][C:8]([OH:10])=[O:9])[CH2:3][CH2:2]1

参加物

5

反応物 2

HCID 712FormaldehydeHCID 15125944-Piperidineacetic acid

生成物 1

HCID 4286192-(1-Methylpiperidin-4-yl)acetic acid

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 962Water溶媒

実験手順

4-Piperidinylacetic acid (4 grams) (28.0 mmoles) from Preparative Example 5A was dissolved in water (50 ml) and 37% formalin (2.72 ml) (33.6 mmoles) was added. The mixture was hydrogenated over 10% Pd-C at 55 psi at 25° C. for 68 hours. The catalyst was filtered off and washed with water. The combined filtrates were evaporated to dryness to give the title compound (MH+ 158).

後処理

  1. filtrationThe catalyst was filtered off
  2. washwashed with water
  3. customThe combined filtrates were evaporated to dryness

出典と根拠

ORDレコード
ord-b8c4978785b145318b998ee872de2e2b
出典データセット
uspto-grants-1997_09
特許番号
US05672611

反応ノート

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