Ethanol → 3-(Difluoromethoxy)benzaldehyde Oxime
反応式
Cl.[NH2:2][OH:3].[OH-].[Na+].[F:6][CH:7]([F:17])[O:8][C:9]1[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=1)[CH:12]=O.C(O)C>O>[F:6][CH:7]([F:17])[O:8][C:9]1[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=1)[CH:12]=[N:2][OH:3]参加物
6
実験手順
A 2.0 g portion of hydroxylamine hydrochloride was dissolved in 12 ml of water and 8 ml of 5N sodium hydroxide was added. A 1.0 g portion of 3-(difluoromethoxy)benzaldehyde was added followed by enough ethanol to give a solution. After 10 minutes of reflux, the reaction mixture was concentrated in vacuo and the residue taken up in 10 ml of water. The pH was adjusted to 4 with hydrochloric acid, then the mixture was extracted with chloroform. The organic phase was dried over sodium sulfate and concentrated, giving the desired compound as an oil.
後処理
- customto give a solution
- temperatureAfter 10 minutes of reflux
- concentrationthe reaction mixture was concentrated in vacuo
- extractionthe mixture was extracted with chloroform
- dry with materialThe organic phase was dried over sodium sulfate
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-dc009ea92b184a389b33de1a2d438e19
- 出典データセット
- uspto-grants-1986_04
- 特許番号
- US04579848
反応ノート
読み込み中…