Ethanol → 3-(Difluoromethoxy)benzaldehyde Oxime

HRID 1380047

反応式

HRID 1380047 の反応式
Cl.[NH2:2][OH:3].[OH-].[Na+].[F:6][CH:7]([F:17])[O:8][C:9]1[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=1)[CH:12]=O.C(O)C>O>[F:6][CH:7]([F:17])[O:8][C:9]1[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=1)[CH:12]=[N:2][OH:3]

参加物

6

反応物 4

HCID 702EthanolHCID 14798Sodium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 27369853-(Difluoromethoxy)benzaldehyde

生成物 1

HCID 861304583-(Difluoromethoxy)benzaldehyde Oxime

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A 2.0 g portion of hydroxylamine hydrochloride was dissolved in 12 ml of water and 8 ml of 5N sodium hydroxide was added. A 1.0 g portion of 3-(difluoromethoxy)benzaldehyde was added followed by enough ethanol to give a solution. After 10 minutes of reflux, the reaction mixture was concentrated in vacuo and the residue taken up in 10 ml of water. The pH was adjusted to 4 with hydrochloric acid, then the mixture was extracted with chloroform. The organic phase was dried over sodium sulfate and concentrated, giving the desired compound as an oil.

後処理

  1. customto give a solution
  2. temperatureAfter 10 minutes of reflux
  3. concentrationthe reaction mixture was concentrated in vacuo
  4. extractionthe mixture was extracted with chloroform
  5. dry with materialThe organic phase was dried over sodium sulfate
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-dc009ea92b184a389b33de1a2d438e19
出典データセット
uspto-grants-1986_04
特許番号
US04579848

関連ノート

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