m-Chloroperbenzoic acid → 1-[8-(Benzyloxy)-1-oxo-1lambda~5~-quinolin-5-yl]ethan-1-one

HRID 1380142ノート

反応式

HRID 1380142 の反応式
[C:1]([C:4]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[C:10]2[C:5]=1[CH:6]=[CH:7][CH:8]=[N:9]2)(=[O:3])[CH3:2].ClC1C=CC=C(C(OO)=[O:30])C=1>C(Cl)(Cl)Cl>[C:1]([C:4]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[C:10]2[C:5]=1[CH:6]=[CH:7][CH:8]=[N+:9]2[O-:30])(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 70297m-Chloroperbenzoic acid2 回HCID 137448911-[8-(Benzyloxy)quinolin-5-yl]ethan-1-one

生成物 1

HCID 137448921-[8-(Benzyloxy)-1-oxo-1lambda~5~-quinolin-5-yl]ethan-1-one

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

5 g of 5-acetyl-8-benzyloxyquinoline are dissolved in 50 ml of chloroform. The solution is ice-cooled and 3.12 g of 80% m-chloroperbenzoic acid are added thereto under stirring. The mixture is stirred at room temperature for 24 hours and at 50° C. for 7.5 hours. The mixture is then stirred at room temperature for 64 hours. 2 g of 80% m-chloroperbenzoic acid are further added to the mixture during the reaction. After the reaction, chloroform is added to the mixture. The mixture is washed with water, a 4% sodium bicarbonate solution and a saturated sodium chloride solution, dried and then evaporated under reduced pressure to remove chloroform. 5-Acetyl-8-benzyloxyquinoline-N-oxide is obtained as yellow solid.

後処理

  1. temperaturecooled
  2. stirringThe mixture is stirred at room temperature for 24 hours and at 50° C. for 7.5 hours
  3. stirringThe mixture is then stirred at room temperature for 64 hours
  4. additionis added to the mixture
  5. washThe mixture is washed with water
  6. dry with materiala 4% sodium bicarbonate solution and a saturated sodium chloride solution, dried
  7. customevaporated under reduced pressure
  8. customto remove chloroform

出典と根拠

ORDレコード
ord-84885a0a360549c1adda6e6a0038d745
出典データセット
uspto-grants-1986_04
特許番号
US04579854

反応ノート

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