Benzenesulfonyl chloride → N-(2-Amino-2-methylpropyl)benzenesulfonamide

HRID 1380591ノート

反応式

HRID 1380591 の反応式
[NH2:1][CH2:2][C:3]([NH2:6])([CH3:5])[CH3:4].[C:7]1([S:13](Cl)(=[O:15])=[O:14])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>C(Cl)(Cl)Cl.N1C=CC=CC=1>[CH3:4][C:3]([NH2:6])([CH3:5])[CH2:2][NH:1][S:13]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)(=[O:15])=[O:14]

参加物

5

反応物 2

HCID 7369Benzenesulfonyl chlorideHCID 131282-Methylpropylenediamine

生成物 1

HCID 23046101N-(2-Amino-2-methylpropyl)benzenesulfonamide収率 79.1%

試薬・触媒・溶媒 2

HCID 1049Pyridine溶媒HCID 6212Chloroform溶媒

反応条件

温度
0 °C

実験手順

To a mixture of 14.97 g (0.169 mol) of 1,2-diamino-2-methylpropane in 300 ml of chloroform and 80 ml pyridine was added 10 g (0.057 mol) of benzenesulfonyl cloride at 0° C. The reaction mixture was stirred at 0° C. for 30 minutes and allowed to reach room temperature. The mixture was evaporated to dryness in vacuo and the residue was partitioned between water and chloroform. Evaporation of the chloroform gave 10.3 g (79%) of semisolid. The product was identified by NMR and IR spectroscopy and elemental analysis.

後処理

  1. customto reach room temperature
  2. customThe mixture was evaporated to dryness in vacuo
  3. customthe residue was partitioned between water and chloroform
  4. customEvaporation of the chloroform

出典と根拠

ORDレコード
ord-3582140b21024839b67edee648677a1f
出典データセット
uspto-grants-1986_04
特許番号
US04582855

反応ノート

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