Hydrochloric Acid → 4-Nitro-3-phenylheptanedioic acid dimethyl ester

HRID 1380930

反応式

HRID 1380930 の反応式
[CH3:1][O:2][C:3](=[O:16])[CH2:4][CH:5]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH2:6][N+:7]([O-:9])=[O:8].[C:17]([O:21][CH3:22])(=[O:20])[CH:18]=[CH2:19].Cl>C(O)(C)(C)C.C(OCC)C>[CH3:1][O:2][C:3](=[O:16])[CH2:4][CH:5]([C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1)[CH:6]([N+:7]([O-:9])=[O:8])[CH2:19][CH2:18][C:17]([O:21][CH3:22])=[O:20]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 7294Methyl AcrylateHCID 10537045Benzenepropanoic acid, b-(nitromethyl)-, methyl ester

生成物 1

HCID 136492464-Nitro-3-phenylheptanedioic acid dimethyl ester

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 6386tert-Butanol溶媒

実験手順

A solution of 356 g of 4-nitro-3-phenylbutanoic acid methyl ester, 138 g of methyl acrylate, and 25 ml of Triton B in 500 ml of t-butanol is allowed to stir at room temperature for 94 hours. Excess aqueous hydrochloric acid (1 N) is added and the solution is diluted with diethyl ether. The organic layer is separated, dried over anhydrous magnesium sulfate and evaporated to give 4-nitro-3-phenylheptanedioic acid dimethyl ester.

後処理

  1. customThe organic layer is separated
  2. dry with materialdried over anhydrous magnesium sulfate
  3. customevaporated

出典と根拠

ORDレコード
ord-3f4c7e6ec30141ae967858d614e0af35
出典データセット
uspto-grants-1986_04
特許番号
US04584313

関連ノート

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