Fuming sulfuric acid → Sulfuric Acid

HRID 1381280ノート

反応式

HRID 1381280 の反応式
ClC1C=C(C=CC=1)NCCC(O)=O.ClC1C=C2C(C(=O)CCN2)=CC=1.[OH:26][S:27]([OH:30])(=[O:29])=[O:28].O=S(=O)=O.F.[B:36]([F:39])([F:38])[F:37]>>[S:27](=[O:28])(=[O:26])([OH:30])[OH:29].[FH:37].[B:36]([F:39])([F:38])[F:37]

参加物

7

反応物 4

HCID 24681Fuming sulfuric acidHCID 889747-Chloro-2,3-dihydro-4-quinoloneHCID 9855450Trifluoroborane HydrofluorideHCID 124709193-((3-Chlorophenyl)amino)propanoic acid

生成物 3

HCID 1118Sulfuric AcidHCID 6356Boron trifluorideHCID 14917Hydrofluoric Acid

実験手順

It should, however, be noted that, in the particular case of the cyclisation of 3-(m-chloroanilino)propionic acid by polyphosphoric acid, a mixture of substantially equal quantities of 5-chloro- and 7-chloro-1,2,3,4-tetrahydro-4-quinolinone is obtained. The selectivity for 7-chloro-1,2,3,4-tetrahydro-4-quinolinone is significantly improved if an oleum or a hydrofluoric acid/boron trifluoride mixture is used as cyclisation agent, but the industrial use of these processes encounters difficulties which result either from the handling of large quantities of sulphuric acid or from the utilisation of a mixture of anhydrous hydrofluoric acid and boron trifluoride.

後処理

  1. customis obtained

出典と根拠

ORDレコード
ord-ff019c51e3c24b779fec4d063a1af4d9
出典データセット
uspto-grants-1986_04
特許番号
US04585867

反応ノート

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