Hydrogen Bromide → 1-Methyl-3-bromopropyldimethylamine hydrobromide

HRID 1381305ノート

反応式

HRID 1381305 の反応式
[CH3:1][CH:2]([N:12]([CH3:14])[CH3:13])[CH2:3][CH2:4]OC1C=CC=CC=1.[BrH:15]>C(Cl)(Cl)Cl>[BrH:15].[CH3:1][CH:2]([N:12]([CH3:14])[CH3:13])[CH2:3][CH2:4][Br:15]

参加物

4

反応物 2

HCID 260Hydrogen BromideHCID 201358801-Methyl-3-phenoxypropyldimethylamine

生成物 1

HCID 201357911-Methyl-3-bromopropyldimethylamine hydrobromide収率 79%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

5 g of the 1-methyl-3-phenoxypropyldimethylamine thus obtained was reacted with 30 ml of 40% hydrobromic acid at 150° C. for 7 hours with stirring. The reaction solution was cooled, 20 ml of chloroform was added and then the solution was separated. The hydrobromic acid was removed under reduced pressure and the residue was recrystallized from 5 ml of ethyl alcohol to give 4.46 g of 1-methyl-3-bromopropyldimethylamine hydrobromide in a yield of 79%.

後処理

  1. temperatureThe reaction solution was cooled
  2. customthe solution was separated
  3. customThe hydrobromic acid was removed under reduced pressure
  4. customthe residue was recrystallized from 5 ml of ethyl alcohol

出典と根拠

ORDレコード
ord-19a6f25ca8774068ae2d3f86dd036288
出典データセット
uspto-grants-1986_04
特許番号
US04585869

反応ノート

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