1-Phenylpiperazine → 1-Phenoxy-4-(4-phenyl-1-piperazinyl)-2-butanol

HRID 1382397ノート

反応式

HRID 1382397 の反応式
[C:1]1([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[CH2:14][CH2:15][CH:16]([OH:25])[CH2:17][O:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.C(=O)([O-])[O-].[Na+].[Na+]>C(O)CCC>[O:18]([CH2:17][CH:16]([OH:25])[CH2:15][CH2:14][N:10]1[CH2:11][CH2:12][N:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:8][CH2:9]1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

参加物

5

反応物 3

HCID 70961-PhenylpiperazineHCID 10340Sodium CarbonateHCID 131203424-Chloro1-phenoxy-2-butanol

生成物 1

HCID 144229031-Phenoxy-4-(4-phenyl-1-piperazinyl)-2-butanol

試薬・触媒・溶媒 1

HCID 2631-Butanol溶媒

実験手順

A mixture of 6.5 g (0.04 mole) of 1-phenylpiperazine, 8.4 g (0.042 mole) of 4-chloro-1-phenoxy-2-butanol and 15.9 g (0.15 mole) of anhydrous sodium carbonate in 200 ml of 1-butanol was heated at reflux 20 hr. The mixture was concentrated under reduced pressure and the residue was partitioned between water and benzene. The benzene layer was washed with water and aqueous saturated sodium chloride solution, dried over sodium sulfate and concentrated under reduced pressure to give the title product in the residue which was recrystallized from isopropyl alcohol to give 8.9 g (68%) of white powder, m.p. 93°-94° C.

後処理

  1. temperaturewas heated
  2. temperatureat reflux 20 hr
  3. concentrationThe mixture was concentrated under reduced pressure
  4. customthe residue was partitioned between water and benzene
  5. washThe benzene layer was washed with water and aqueous saturated sodium chloride solution
  6. dry with materialdried over sodium sulfate
  7. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-303220ce004d4fad8b1340743f36b87e
出典データセット
uspto-grants-1989_02
特許番号
US04806555

反応ノート

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