N-Iodosuccinimide → HCID 21188049、化合物
反応式
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([Cl:12])[C:3]=1[N:13]1[C:17]([CH3:18])=[CH:16][C:15]([CH3:19])=[N:14]1.[I:20]N1C(=O)CCC1=O>C(#N)C>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:9])([F:10])[F:11])[CH:5]=[C:4]([Cl:12])[C:3]=1[N:13]1[C:17]([CH3:18])=[C:16]([I:20])[C:15]([CH3:19])=[N:14]1参加物
4
実験手順
To a stirred solution of 1-(2,6-dichloro-4-trifluoromethylphenyl)-3,5-dimethylpyrazole (0.218 g) in acetonitrile (3 ml) at room temperature was added dropwise a solution of N-iodosuccinimide (0.158 g) in acetonitrile (2 ml). After 27 hours the mixture was evaporated to dryness and the residue purified by column chromatography on silica gel (5 g) eluted with dichloromethane. Combination and evaporation of suitable fractions provided the title compound as yellow oil.