1-Phenylpiperazine → 1-Phenyl-4-[(5-phenyl-3-pyridyl)methyl]piperazine

HRID 1384074ノート

反応式

HRID 1384074 の反応式
Cl[CH2:2][C:3]1[CH:4]=[N:5][CH:6]=[C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:8]=1.CC1C=NC=C(C2C=CC=CC=2)C=1.[C:28]1([N:34]2[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]2)[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>C(#N)C>[C:28]1([N:34]2[CH2:39][CH2:38][N:37]([CH2:2][C:3]3[CH:4]=[N:5][CH:6]=[C:7]([C:9]4[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=4)[CH:8]=3)[CH2:36][CH2:35]2)[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1

参加物

5

反応物 3

HCID 70961-PhenylpiperazineHCID 5981363-Methyl-5-phenylpyridineHCID 110849253-(Chloromethyl)-5-phenylpyridine

生成物 1

HCID 111210471-Phenyl-4-[(5-phenyl-3-pyridyl)methyl]piperazine

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

2.04 g of 3-chloromethyl-5-phenylpyridine (“A”) [obtainable for example by radical chlorination of 3-methyl-5-phenylpyridine] and 1.62 g of 1-phenylpiperazine are dissolved in 200 ml of acetonitrile and the mixture is stirred for six hours at room temperature. After customary work-up, 1-phenyl-4-[(5-phenyl-3-pyridyl)methyl]piperazine, m.p. 83-85°, is obtained.

出典と根拠

ORDレコード
ord-015cfc50b8e94d0ebd10ef31c4dde1af
出典データセット
uspto-grants-2001_07
特許番号
US06258813B1

反応ノート

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