Methyl iodide → Ethyl 6-chloro-1-methyl-1H-indole-2-carboxylate

反応式

[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[C:7]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[NH:8]2)=[CH:4][CH:3]=1.[H-].[Na+].I[CH3:19]>>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[C:7]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[N:8]2[CH3:19])=[CH:4][CH:3]=1

参加物

反応物 3

HCID 6328Methyl iodide

HCID 24758Sodium hydride

HCID 7015027Ethyl 6-chloroindole-2-carboxylate

生成物 1

HCID 10561874Ethyl 6-chloro-1-methyl-1H-indole-2-carboxylate

実験手順

The preparation is carried out as in Example 1.1, from 8.0 g (35.8 mmol) of ethyl 6-chloro-1H-indole-2-carboxylate, from 1.8 g of 60% sodium hydride and from 2.8 ml of iodomethane.

出典と根拠

ORDレコード: ord-be5e25e27a6846618217e2d7563ceecf
出典データセット: uspto-grants-2001_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06262045B1

反応ノート

読み込み中…