Sodium borohydride → 6-Ethoxytetralin-2-ol

HRID 1385892

反応式

HRID 1385892 の反応式
[BH4-].[Na+].[CH2:3]([O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[CH2:12][C:11](=[O:16])[CH2:10][CH2:9]2)[CH3:4]>C(O)C.[OH-].[Na+]>[CH2:3]([O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[CH2:12][CH:11]([OH:16])[CH2:10][CH2:9]2)[CH3:4]

参加物

5

反応物 2

HCID 4311764Sodium borohydrideHCID 46940316-Ethoxy-2-tetralone

生成物 1

HCID 118302726-Ethoxytetralin-2-ol

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 14798Sodium Hydroxide溶媒

反応条件

温度
0 °C

実験手順

1.97 g (52 mmol) of sodium borohydride were added in portions of 0° C. to 9.8 g (51.4 mmol) of 6-ethoxy-2-tetralone in 150 ml of ethanol. The mixture was stirred for 1 hour at 0° C. and diluted with 200 ml of 2N sodium hydroxide solution, and the solution was extracted with dichloromethane. The combined organic phases were washed with saturated sodium chloride solution, dried and concentrated. This gave 9.8 g of an oil which was further reacted without purification.

後処理

  1. extractionthe solution was extracted with dichloromethane
  2. washThe combined organic phases were washed with saturated sodium chloride solution
  3. customdried
  4. concentrationconcentrated
  5. customThis gave 9.8 g of an oil which was further reacted without purification

出典と根拠

ORDレコード
ord-39e1cd72b30b4ec9b1d6e51fdb92caea
出典データセット
uspto-grants-2001_07
特許番号
US06265398B1

関連ノート

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