Potassium Iodide → HCID 21717342、化合物

HRID 1386076ノート

反応式

HRID 1386076 の反応式
[NH2:1][C:2]1[C:3]2[N:4]([C:9]([CH3:13])=[C:10]([CH3:12])[N:11]=2)[CH:5]=[C:6]([CH3:8])[CH:7]=1.[CH2:14]([C:16]1[CH:23]=[C:22]([F:24])[CH:21]=[C:20]([CH3:25])[C:17]=1[CH2:18]Br)[CH3:15].[I-].[K+].C([O-])([O-])=O.[Na+].[Na+]>C(COC)OC>[CH2:14]([C:16]1[CH:23]=[C:22]([F:24])[CH:21]=[C:20]([CH3:25])[C:17]=1[CH2:18][NH:1][C:2]1[C:3]2[N:4]([C:9]([CH3:13])=[C:10]([CH3:12])[N:11]=2)[CH:5]=[C:6]([CH3:8])[CH:7]=1)[CH3:15]

参加物

6

反応物 4

HCID 4875Potassium IodideHCID 10340Sodium CarbonateHCID 21717327HCID 21717327、化合物HCID 226726328-Amino-2,3,6-trimethylimidazo[1,2-a]pyridine

生成物 1

HCID 21717342HCID 21717342、化合物収率 29%

試薬・触媒・溶媒 1

HCID 80711,2-Dimethoxyethane溶媒

実験手順

8-Amino-2,3,6-trimethylimidazo[1,2-a]pyridine (0.38 g, 2.16 mmol) and 2-ethyl-4-fluoro-6-methylbenzylbromide (0.50 g, 2.16 mmol) were dissolved in 10 ml dimethoxyethane. Potassium iodide (0.2 g, 1.2 mmol) and Na2CO3 (0.4 g, 3.8 mmol) were added and the mixture was refluxed for 6 hours. The solvent was evaporated and the residue was purified by column chromatography on silica gel using a mixture of methylene chloride and ethyl acetate (60:40) as eluent. 203 mg (29%) of the title compound was obtained.

後処理

  1. temperaturethe mixture was refluxed for 6 hours
  2. customThe solvent was evaporated
  3. customthe residue was purified by column chromatography on silica gel using
  4. additiona mixture of methylene chloride and ethyl acetate (60:40) as eluent

出典と根拠

ORDレコード
ord-14bc3e2bfc4f43fc9ca11e04c3ae6f34
出典データセット
uspto-grants-2001_07
特許番号
US06265415B1

反応ノート

読み込み中…