N-(4-Bromophenyl)-2-chloroacetamide → N-(4-bromophenyl)-2-(pyrrolidin-1-yl)acetamide
反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:12])[CH2:10]Cl)=[CH:4][CH:3]=1.[NH:13]1[CH2:17][CH2:16][CH2:15][CH2:14]1>C1COCC1>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:12])[CH2:10][N:13]2[CH2:17][CH2:16][CH2:15][CH2:14]2)=[CH:4][CH:3]=1参加物
4
実験手順
A solution of 5.0 g (0.02 mol) of N-(4-bromophenyl)-α-chloroacetamide (Part A) and 5.05 mL (0.06 mol) of pyrrolidine in 100 mL of THF was stirred overnight at ambient temperature. The mixture was concentrated in vacuo and the residue was partitioned between H2O and EtOAc. The organic layer was separated, washed with H2O, dried over Na2SO4, filtered, and evaporated in vacuo to afford 5.74 g of analytically pure title compound as crystals.
後処理
- concentrationThe mixture was concentrated in vacuo
- customthe residue was partitioned between H2O and EtOAc
- customThe organic layer was separated
- washwashed with H2O
- dry with materialdried over Na2SO4
- filtrationfiltered
- customevaporated in vacuo
出典と根拠
- ORDレコード
- ord-846bec2310514558b4c8c7ac7758e998
- 出典データセット
- uspto-grants-2001_07
- 特許番号
- US06265575B1
反応ノート
読み込み中…