Pyridine → HCID 799182、化合物

HRID 1387695ノート

反応式

HRID 1387695 の反応式
[C:1]([O:10][CH3:11])(=[O:9])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[NH2:4].N1C=CC=CC=1.[CH3:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([S:26](Cl)(=[O:28])=[O:27])=[CH:22][CH:21]=1>C(Cl)(Cl)Cl>[CH3:11][O:10][C:1](=[O:9])[C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH:4][S:26]([C:23]1[CH:22]=[CH:21][C:20]([O:19][CH3:18])=[CH:25][CH:24]=1)(=[O:28])=[O:27]

参加物

5

反応物 3

HCID 1049PyridineHCID 74014-Methoxybenzenesulfonyl chlorideHCID 8635Methyl Anthranilate

生成物 1

HCID 799182HCID 799182、化合物収率 88.6%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

To a solution of 2.00 g (0.013 mol) of methyl anthranilate dissolved in 20 mL of chloroform was added 3.2 mL (0.039 mol) of pyridine followed by 2.733 g (0.013 mol) of p-methoxybenzenesulfonyl chloride. The reaction mixture was stirred at room temperature for 5 h and then washed with 3N HCl and water. The organics were then dried over Na2SO4, filtered and concentrated in vacuo. The resulting white solid was washed with ether and dried in vacuo to provide 3.7 g (87%) of the desired sulfonamide. CI Mass Spec: 322 (M+H).

後処理

  1. washwashed with 3N HCl and water
  2. dry with materialThe organics were then dried over Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo
  5. washThe resulting white solid was washed with ether
  6. customdried in vacuo

出典と根拠

ORDレコード
ord-416ea893809444bca5e7a77caf10b9e3
出典データセット
uspto-grants-2001_07
特許番号
US06268504B1

反応ノート

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