Methyl iodide → Methyl 3-fluoro-4-(hexadecylamino)benzoate

HRID 1389090ノート

反応式

HRID 1389090 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[NH:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[C:5]([OH:7])=[O:6].[H-].[Na+].[CH3:30]I>CN(C)P(N(C)C)(N(C)C)=O>[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[NH:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[C:5]([O:7][CH3:30])=[O:6]

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 205364103-Fluoro-4-(hexadecylamino)benzoic acid

生成物 1

HCID 20536536Methyl 3-fluoro-4-(hexadecylamino)benzoate

試薬・触媒・溶媒 1

HCID 12679Hexamethylphosphoramide溶媒2 回

反応条件

温度
25 °C

実験手順

A solution of 7.20 g of 3-fluoro-4-(hexadecylamino)-benzoic acid in 25 ml of hexamethylphosphoramide is added to a stirred mixture of 0.800 g of sodium hydride (57% in mineral oil) and 25 ml of hexamethylphosphoramide. The solution which forms after one hour is treated with 11.0 g of methyl iodide and is then stirred at 25° C. for 18 hours. Dilution with water followed by filtration affords a white solid which is crystallized from ethanol to yield methyl 3-fluoro-4-(hexadecylamino)-benzoate as a white solid.

後処理

  1. filtrationDilution with water followed by filtration
  2. customaffords a white solid which
  3. customis crystallized from ethanol

出典と根拠

ORDレコード
ord-096dd56e6bf04a449303eb0049156266
出典データセット
uspto-grants-1981_01
特許番号
US04243609

反応ノート

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