Methyl iodide → 2,2-Dimethylhexanenitrile

HRID 1389174

反応式

HRID 1389174 の反応式
[CH3:1][C:2]([CH3:9])([CH2:5][CH2:6][CH2:7][CH3:8])[CH2:3][NH2:4].C(#N)CCCCC.CI.[NH2-].[Na+]>O.C1(C)C=CC=CC=1>[CH3:1][C:2]([CH3:9])([CH2:5][CH2:6][CH2:7][CH3:8])[C:3]#[N:4]

参加物

7

反応物 4

HCID 6328Methyl iodideHCID 12352HexanenitrileHCID 24533Sodium amideHCID 543253312,2-Dimethylhexan-1-amine

生成物 1

HCID 35735622,2-Dimethylhexanenitrile収率 81%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 1140Toluene溶媒2 回

実験手順

2,2-Dimethylhex-1-ylamine. A solution of capronitrile (25 g., 0.26 mole) and methyl iodide (75 g., 0.53 mole) in 80 ml. of dry toluene is warmed to 80° and treated gradually with a suspension of sodium amide (25.4 g., 0.65 mole) in 100 ml. of toluene at a rate sufficient to maintain general reflux. After addition is complete, the mixture is stirred and refluxed for an additional 2 hr. period, cooled and treated with 150 ml. of water. The organic layer is separated, washed with water and dried over magnesium sulfate. Concentration of the dried solution under reduced pressure and distillation of residual material affords an 81% yield of 2,2-dimethylcapronitrile.

後処理

  1. temperaturereflux
  2. additionAfter addition
  3. temperaturerefluxed for an additional 2 hr
  4. temperatureperiod, cooled
  5. additiontreated with 150 ml
  6. customThe organic layer is separated
  7. washwashed with water
  8. dry with materialdried over magnesium sulfate
  9. distillationConcentration of the dried solution under reduced pressure and distillation of residual material

出典と根拠

ORDレコード
ord-b10eaa5a65e849c58391f3ae0f7ee78e
出典データセット
uspto-grants-1981_01
特許番号
US04243681

関連ノート

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