Hydrogen Bromide → 4-(2'-Hydroxyethoxy)-piperidine hydrobromide
反応式
C([N:8]1[CH2:13][CH2:12][CH:11]([O:14][CH2:15][CH2:16][OH:17])[CH2:10][CH2:9]1)C1C=CC=CC=1.[BrH:18].[H][H]>C(O)C.[Pd]>[BrH:18].[OH:17][CH2:16][CH2:15][O:14][CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1参加物
6
実験手順
A solution of (B) (12 g) in ethanol (200 ml) was neutralized with an ethanolic solution of hydrogen bromide and hydrogenated in the presence of 10% palladium on carbon (2.4 g). After 5 hours the uptake of hydrogen ceased and the catalyst was removed by filtration. The filtrate was taken to dryness in vacuo to give (C) as a semicrystalline solid.
後処理
- customthe catalyst was removed by filtration
出典と根拠
- ORDレコード
- ord-939c151a292345a6892d6121f3d4fa37
- 出典データセット
- uspto-grants-1981_01
- 特許番号
- US04246262
反応ノート
読み込み中…