Hydrochloric Acid → Mirabegron

HRID 1392375ノート

反応式

HRID 1392375 の反応式
Cl.[NH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][NH:11][CH2:12][C@@H:13]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[OH:14])=[CH:5][CH:4]=1.[NH2:21][C:22]1[S:23][CH:24]=[C:25]([CH2:27][C:28](O)=[O:29])[N:26]=1.Cl.Cl.CN(C)CCCN=C=NCC.[OH-].[Na+]>O>[NH2:21][C:22]1[S:23][CH:24]=[C:25]([CH2:27][C:28]([NH:2][C:3]2[CH:4]=[CH:5][C:6]([CH2:9][CH2:10][NH:11][CH2:12][C@H:13]([OH:14])[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=3)=[CH:7][CH:8]=2)=[O:29])[N:26]=1

参加物

7

反応物 5

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 34665(2-Amino-1,3-thiazol-4-yl)acetic acidHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 529530072-((4-Aminophenethyl)amino)-1-phenylethanol hydrochloride, (R)-

生成物 1

HCID 9865528Mirabegron

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

To a mixed solution of 13.50 kg of (R)-2-[[2-(4-aminophenyl) ethyl]amino]-1-phenylethanol monohydrochloride, 7.29 kg of 2-aminothiazol-4-yl-acetic acid, 4.46 kg of concentrated hydrochloric acid and 270 L of water, 9.73 kg of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide monohydrochloride (EDC) was added at 15° C., and the mixture was stirred for one hour. A mixed solution of 4.10 kg of sodium hydroxide and 110 L of water was dropped in the reaction solution, thereby undergoing crystallization. A generated crystal was collected by filtration and washed with water to obtain 26.2 kg of a wet cake of the β-form crystal of (R)-2-(2-aminothiazol-4-yl)-4′-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide. This crystal was used for recrystallization as it was in the wet state.

後処理

  1. customcrystallization
  2. filtrationA generated crystal was collected by filtration
  3. washwashed with water

出典と根拠

ORDレコード
ord-7321fc6bd2354790823bd707d4a288b5
出典データセット
uspto-grants-2008_03
特許番号
US07342117B2

反応ノート

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