Chloroacetyl chloride → 2,4'-Dichloroacetanilide

HRID 1392774

反応式

HRID 1392774 の反応式
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[Cl:9][CH2:10][C:11](Cl)=[O:12]>C(OCC)(=O)C>[Cl:9][CH2:10][C:11]([NH:6][C:5]1[CH:7]=[CH:8][C:2]([Cl:1])=[CH:3][CH:4]=1)=[O:12]

参加物

4

反応物 2

HCID 6577Chloroacetyl chlorideHCID 78124-Chloroaniline

生成物 1

HCID 949202,4'-Dichloroacetanilide

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

p-Chloroaniline (3.82 g) was dissolved in ethyl acetate (30 ml), and chloroacetyl chloride (2.39 ml) was added at room temperature to stir the mixture for 1 hour. After the reaction mixture was heated and stirred at 60° C. for 3.5 hours, crystals deposited were collected by filtration to obtain the title compound (4.78 g). The filtrate was concentrated to about ¼, and crystals deposited were collected by filtration to obtain the title compound (1.01 g).

後処理

  1. temperatureAfter the reaction mixture was heated
  2. stirringstirred at 60° C. for 3.5 hours
  3. filtrationcrystals deposited were collected by filtration

出典と根拠

ORDレコード
ord-79bce5c5288947b394969739bdff7dea
出典データセット
uspto-grants-2008_03
特許番号
US07342014B2

関連ノート

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