Water → 1-(4-Tert-butylphenyl)ethane-1,2-diol

HRID 1392884ノート

反応式

HRID 1392884 の反応式
[C:1](O)([CH3:4])([CH3:3])[CH3:2].C([CH:10]=[CH:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)(C)(C)C.S([O-])([O-])=[O:19].[Na+].[Na+].[OH2:24]>>[C:1]([C:15]1[CH:14]=[CH:13][C:12]([CH:11]([OH:19])[CH2:10][OH:24])=[CH:17][CH:16]=1)([CH3:4])([CH3:3])[CH3:2]

参加物

5

反応物 4

HCID 962WaterHCID 6386tert-ButanolHCID 24437Sodium SulfiteHCID 138033tert-Butylstyrene

生成物 1

HCID 190777511-(4-Tert-butylphenyl)ethane-1,2-diol

実験手順

To a 100 ml round bottom flask is added 20 ml tert butanol, 20 ml of water and 5.6 g of AD-mix-P. The solution is stirred and cooled to 0° C. tert-butyl styrene (0.64 g, 4 mmol) is added to the mixture and the resulting solution is stirred overnight at 0 C. Solid sodium sulfite (6 g) is added and the mixture stirred for an additional 30 minutes. The solution is then extracted in ethyl acetate, washed with water and dried. The crude is then purified by flash chromatography (silica gel; ethyl acetate/hexanes) to afford the product.

後処理

  1. additionis added to the mixture
  2. stirringthe resulting solution is stirred overnight at 0 C
  3. stirringthe mixture stirred for an additional 30 minutes
  4. extractionThe solution is then extracted in ethyl acetate
  5. washwashed with water
  6. customdried
  7. customThe crude is then purified by flash chromatography (silica gel; ethyl acetate/hexanes)
  8. customto afford the product

出典と根拠

ORDレコード
ord-b473e69c76fc45c2bc52fabd7125d26e
出典データセット
uspto-grants-2008_03
特許番号
US07344702B2

反応ノート

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