Chloroform → 7,9-Dibromo-beta-carboline hydrochloride

HRID 1393976ノート

反応式

HRID 1393976 の反応式
[Br:1][C:2]1[CH:14]=[C:13]2[C:5]([C:6]3[CH:7]=[CH:8][N:9]=[CH:10][C:11]=3[NH:12]2)=[CH:4][CH:3]=1.[Br:15]Br.C(Cl)(Cl)[Cl:18]>C1COCC1>[ClH:18].[Br:1][C:2]1[CH:14]=[C:13]2[C:5]([C:6]3[CH:7]=[CH:8][N:9]=[CH:10][C:11]=3[N:12]2[Br:15])=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 6212ChloroformHCID 24408BromineHCID 145928Eudistomin O

生成物 1

HCID 221852417,9-Dibromo-beta-carboline hydrochloride

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of the product from example 1 (140 mg, 0.58 mmol) in THF (2 ml) was treated with bromine (0.50 ml). After 10 min at RT, the reaction was diluted with chloroform and the product was filtered. The filtered product was taken up in methanol and treated with 1M HCl in ether and concentrated. The residue was triturated with ether to provide 160 mg of 7,9-dibromo-β-carboline hydrochloride.

後処理

  1. filtrationthe product was filtered
  2. additiontreated with 1M HCl in ether
  3. concentrationconcentrated
  4. customThe residue was triturated with ether

出典と根拠

ORDレコード
ord-211396885c9740f4af7d0f49fd64b55d
出典データセット
uspto-grants-2008_03
特許番号
US07348336B2

反応ノート

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