Hydrochloric Acid → 2-[(4-Acetylphenyl)sulfanyl]acetic acid
反応式
C[O:2][C:3](=[O:15])[CH2:4][S:5][C:6]1[CH:11]=[CH:10][C:9]([C:12](=[O:14])[CH3:13])=[CH:8][CH:7]=1.[Li+].[OH-].Cl>C1COCC1.O>[C:12]([C:9]1[CH:8]=[CH:7][C:6]([S:5][CH2:4][C:3]([OH:15])=[O:2])=[CH:11][CH:10]=1)(=[O:14])[CH3:13]参加物
6
実験手順
(4-Acetyl-phenylsulfanyl)-acetic acid methyl ester (1.48 g, 6.6 mmol) is dissolved in THF (40 ml). To this solution is added LiOH (415 mg, 9.9 mmol) in water (10 ml), and the mixture was stirred at ambient temperature overnight. The mixture was acidified to pH 5 using 1N HCl and then extracted with ethyl acetate (3×25 ml). The combined organic layers were dried over MgSO4 and concentrated in vacuo to yield (4-acetyl-phenylsulfanyl)-acetic acid as a white solid (1.27 g, 91%).
後処理
- extractionextracted with ethyl acetate (3×25 ml)
- dry with materialThe combined organic layers were dried over MgSO4
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-05a509e742ff42c28946960fd75c152b
- 出典データセット
- uspto-grants-2008_03
- 特許番号
- US07348359B2
反応ノート
読み込み中…