Hexamethylenetetramine → 1-[(3-Phenyl-5-isoxazolyl)methyl]-3,5,7-triaza-1-azoniaadamantane bromide
反応式
[Br:1][CH2:2][C:3]1[O:7][N:6]=[C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:4]=1.[CH2:14]1[N:19]2[CH2:20][N:21]3[CH2:23][N:17]([CH2:18]2)[CH2:16][N:15]1[CH2:22]3>C(Cl)(Cl)Cl>[Br-:1].[C:8]1([C:5]2[CH:4]=[C:3]([CH2:2][N+:15]34[CH2:16][N:17]5[CH2:23][N:21]([CH2:20][N:19]([CH2:18]5)[CH2:14]3)[CH2:22]4)[O:7][N:6]=2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1参加物
4
実験手順
A 90 g. portion of the product of Example 1 was dissolved in 1.5 l. of chloroform and 70 g. of hexamethylenetetramine was added. The mixture was stirred at reflux temperature for 4 hours, and was filtered hot. The solids were dried under vacuum to obtain 143 g. of impure product, m.p. 159°-160°, which contained about 93 percent product and 7 percent hexamethylenetetramine.