Pyridine → N1-(6-Chloropyridin-2-yl)-N2,N2-dimethylethane-1,2-diamine
反応式
Cl[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[N:3]=1.C[NH:10][CH2:11][CH2:12][NH:13][CH3:14].N1C=CC=C[CH:16]=1>>[CH3:16][N:13]([CH3:14])[CH2:12][CH2:11][NH:10][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[N:3]=1参加物
4
実験手順
A solution of 2,6-dichloropyridine (29.6 g., 0.20 mole) and unsymmetrical dimethylethylenediamine (52.9 g., 0.60 mole) in 100 ml of pyridine is stirred at reflux for 48 hours. The pyridine is removed under reduced pressure and the residual mixture is poured into water and made basic with excess sodium hydroxide. The product is extracted into ethyl acetate which is then concentrated and the residual oil is distilled. 2-(2-Dimethylaminoethylamino)-6-chloropyridine boiling at 104°-105° at 0.2 mm is collected in 70% yield.
後処理
- temperatureat reflux for 48 hours
- customThe pyridine is removed under reduced pressure
- additionthe residual mixture is poured into water
- extractionThe product is extracted into ethyl acetate which
- concentrationis then concentrated
- distillationthe residual oil is distilled
- custom2-(2-Dimethylaminoethylamino)-6-chloropyridine boiling at 104°-105° at 0.2 mm is collected in 70% yield
出典と根拠
- ORDレコード
- ord-3aad83be6d564b87924b3fa512e8ba83
- 出典データセット
- uspto-grants-1980_05
- 特許番号
- US04203988
反応ノート
読み込み中…