N,N,6-trimethyl-5-nitropyridin-2-amine → N2,N2,6-trimethylpyridine-2,5-diamine

HRID 1398861ノート

反応式

HRID 1398861 の反応式
[CH3:1][N:2]([CH3:13])[C:3]1[CH:8]=[CH:7][C:6]([N+:9]([O-])=O)=[C:5]([CH3:12])[N:4]=1>O1CCCC1.[Pd]>[CH3:1][N:2]([CH3:13])[C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[C:5]([CH3:12])[N:4]=1

参加物

4

反応物 1

HCID 59613085N,N,6-trimethyl-5-nitropyridin-2-amine

生成物 1

HCID 20748032N2,N2,6-trimethylpyridine-2,5-diamine収率 100%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of N,N,6-trimethyl-5-nitropyridin-2-amine (2.73 g, 15.1 mmol) in tetrahydrofuran (50 mL) was added 10% palladium on carbon (50% wet, 273 mg), and the mixture was purged with hydrogen and stirred under balloon pressure hydrogen at room temperature for 14 hr. The catalyst was removed by filtration, and the filtrate was concentrated in vacuo to give the title compound as a brown solid (2.30 g, 15.1 mmol).

後処理

  1. customthe mixture was purged with hydrogen
  2. customThe catalyst was removed by filtration
  3. concentrationthe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-0c47b4cebc9044bbaced7217322c58ff
出典データセット
uspto-grants-2014_12
特許番号
US08901141B2

反応ノート

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