Lithium Hydroxide → HCID 67467360、化合物
反応式
C[O:2][C:3]([C:5]1[CH:6]=[C:7]([F:14])[CH:8]=[C:9]2[S:13][CH:12]=[N:11][C:10]=12)=[O:4].[OH-].[Li+]>O1CCCC1>[F:14][C:7]1[CH:8]=[C:9]2[S:13][CH:12]=[N:11][C:10]2=[C:5]([C:3]([OH:4])=[O:2])[CH:6]=1参加物
4
実験手順
To a solution of 6-fluoro-benzothiazole-4-carboxylic acid methyl ester (1.97 g, 9.33 mmol) in tetrahydrofuran (30 mL) was added aqueous lithium hydroxide solution (2M, 14.0 mL, 28 mmol, 3 eq.) and then stirred, at room temperature, for 4 hr. The reaction mixture was quenched with aqueous hydrochloric acid (2M, 30 mL) and stirred for 15 min. The resulting suspension was filtered and the solid produced was washed with water and air dried to give the title compound as a grey solid (1.51 g, 82%).
後処理
- customThe reaction mixture was quenched with aqueous hydrochloric acid (2M, 30 mL)
- stirringstirred for 15 min
- filtrationThe resulting suspension was filtered
- customthe solid produced
- washwas washed with water and air
- customdried
出典と根拠
- ORDレコード
- ord-4bf6b7af6c3740719a1f51777b9d8357
- 出典データセット
- uspto-grants-2014_12
- 特許番号
- US08916593B2
反応ノート
読み込み中…