Methyl iodide → HCID 67230764、化合物
反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([N+:19]([O-:21])=[O:20])[C:11]=1[NH:12][C:13](=O)C(F)(F)F)[C:5]([O:7][CH3:8])=[O:6].C([O-])([O-])=O.[Cs+].[Cs+].CI>C(#N)C>[Br:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([N+:19]([O-:21])=[O:20])[C:11]=1[NH:12][CH3:13])[C:5]([O:7][CH3:8])=[O:6]参加物
5
反応条件
- 温度
- 45 °C
実験手順
To methyl 3-bromo-5-nitro-4-(2,2,2-trifluoroacetamido)-benzoate (9.69 g, 26.1 mmol) in 250 mL acetonitrile was added Cs2CO3 (10.2 g, 31.3 mmol) and methyliodide (3.3 mL, 52.2 mmol). The mixture was heated to 45° C. for 2 h. The solvent was removed in vac. Water and methanol were added and stirred for 20 minutes. The solid was filtered and washed with methanol.
後処理
- customThe solvent was removed in vac
- additionWater and methanol were added
- filtrationThe solid was filtered
- washwashed with methanol
出典と根拠
- ORDレコード
- ord-8d84165c12444686ad786dce8a78271e
- 出典データセット
- uspto-grants-2014_12
- 特許番号
- US08916599B2
反応ノート
読み込み中…